Interstitial cells of Cajal: a new perspective on smooth muscle function
نویسندگان
چکیده
منابع مشابه
Nitrergic relaxation of gastrointestinal smooth muscle: role of interstitial cells of Cajal and smooth muscle cells
Background The signaling molecule nitric oxide (NO) is known to activate the enzyme NO-sensitive guanylyl cyclase (NOGC). By generation of the intracellular second messenger cGMP NO-GC regulates many physiological processes. In the gastrointestinal (GI) tract nitrergic neurons are part of the enteric nervous system which regulates GI motility. In addition, interstitial cells of Cajal (ICC) are ...
متن کاملInterstitial cells: regulators of smooth muscle function.
Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells. Interstitial cells of mesenchymal origin interact with and form electrical connectivity with smooth muscle cells in many organs, and these cells provide important regulatory functions. For example, in the gastrointestinal tract, interstitial cells of Cajal (ICC) and PDGFRα(+) cells have been described,...
متن کاملActivation of intestinal smooth muscle cells by interstitial cells of Cajal in simulation studies.
Activation of a two-dimensional sheet network (5 parallel chains of 5 cells each) of simulated intestinal smooth muscle cells (SMCs) by one interstitial cell of Cajal (ICC) was modeled by PSpice simulation. The network of 25 cells was not interconnected by gap-junction channels; instead, excitation was transmitted by the electric field that develops in the junctional clefts (JC) when the prejun...
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The murine jejunum and lower esophageal sphincter (LES) were examined to determine the locations of various signaling molecules and their colocalization with caveolin-1 and one another. Caveolin-1 was present in punctate sites of the plasma membranes (PM) of all smooth muscles and diffusely in all classes of interstitial cells of Cajal (ICC; identified by c-kit immunoreactivity), ICC-myenteric ...
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1 Department of Medicine, Farncombe Family Intestinal Health Research Institute, McMaster University, Hamilton, ON, Canada 2 Department of Gastroenterology and Hepatology, Wuhan University Institute of Digestive and Liver diseases, Renmin Hospital of Wuhan University, Wuhan, China 3 Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark *Correspondence: hui...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2006
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2006.115279